A Crack in Creation by Jennifer Doudna & Samuel Sternberg
The New Power to Control EvolutionFor a long time I have question the central dogma of Molecular Biology & Evolution. Can it just be DNA Replication, Transcription and Translation, coupled with Random Mutation that can account for all of life and it's diversity?
Are we just expressions of a Genetic Machine?
I vacillate continuously between believing in this dogma and entertaining more spiritual beliefs. There's not much I can do about it. My mind says on thing, my heart (based on some wild experiences) say something else.
You can buy the book here.
What is CRISPR-cas9?
Videos by Thermofisher
Understanding CRISPR-cas9 and Other Ideas in Genetics
- Get a short ebook on CRISPR-cas9 here.
- Homologous Recombination. This is a DNA repair mechanism used by our cells to correct for errors caused by damage from example radiation or carcinogens. Scientists have learned to use this mechanism to insert synthetic genes into target locations. This is now called Gene Editing.
ChromothripsisChromothripsis is the phenomenon by which up to thousands of clustered chromosomal rearrangements occur in a single event in localised and confined genomic regions in one or a few chromosomes, and is known to be involved in both cancer and congenital diseases. It occurs through one massive genomic rearrangement during a single catastrophic event in the cell's history. It is believed that for the cell to be able to withstand such a destructive event, the occurrence of such an event must be the upper limit of what a cell can tolerate and survive. The chromothripsis phenomenon opposes the conventional theory that cancer is the gradual acquisition of genomic rearrangements and somatic mutations over time.
Chromothripis @ Wikipedia
The Gene Casino.
Dna replication transcription and translationGood Slides to Study.
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